PHARMACOLOGY & TOXICOLOGY

Pharmacology studies the effects of drugs/pharmaceuticals and other xenobiotics on living systems, as well as their development and chemical properties. Toxicology evaluates the toxic effects of substances in preclinical studies and clinical trials with the aim of ensuring that their benefits outweigh their risks. Impactys provides a wide range of pharmacological & toxicological solutions, including:

  • Drug Effects
    • Receptor-mediated transport
    • Enzyme inhibition and activation
    • Transcription, translation, and metabolism
    • Cell proliferation, cytostatic, or cytotoxic effects
    • Stem cell marker expression
    • Receptor binding and activation
  • Drug Metabolism
    • Receptor- and protein-mediated transport
    • Transient and stable transfection
    • Electroporation
    • Subcellular localization
    • Mechanisms of internalization
  • Toxicology
    • Cytokine release
    • Bacterial endotoxin (LAL)
    • Determining potential cytotoxicities in target tissues
    • Elucidating toxicity mechanisms
    • Drug screening to prevent cytotoxicity
    • Cytochrome P450 induction studies
    • Cr51 release
    • Protein metabolism
    • DNA synthesis
    • RNA synthesis
    • Dose range-finding investigation
    • Hemolysis
    • Plaque titering assays
    • In vitro cytogenetics