Cell Biology

Cell biology studies the structure, physiology, growth, reproduction, and death of cells. In practice, cell biology uses microscopic and molecular tools to examine all cell types, from unicellular prokaryotes to specialized eukaryotic cells that constitute multicellular organisms. Impactys provides a wide range of cell biology solutions, including:

Cell-Based Assays
- High-throughput screening (HTS)
- Electrochemiluminescence (ESL)
- Cell proliferation
- Cell death (necrosis, apoptosis)
- Stem cell differentiation
- Cell metabolism
- Protein turnover
- Molecular labeling (radioactive, fluorescent, colorimetric)
- Subcellular fractionation
- Flow cytometry
- Phase and fluorescence microscopy
- Cell receptor binding, activation, and turnover
- Cell signaling
- Immunocytochemistry
- Reporter gene assays
Tissue Culture
Commercial cell lines

Primary cell isolation and culture

Stem cell culture

Adherent & suspension cultures

Cell culture systems (static, roller bottle, membrane, porous bead, hollow fiber bioreactor, glass, plastic)

High-density tissue culture media optimization, serum-free adaptation

Cell cloning and selection

DNA transfection
Drug Actions On Cells
- Receptor-mediated transport
- Enzyme inhibition and activation
- Transcription, translation, and metabolism
- Cell proliferation, cytostatic, or cytotoxic effects
- Stem cell marker expression
- Receptor binding and activation
Drug Metabolism
- Receptor- and protein-mediated transport
- Transient and stable transfection
- Electroporation
- Subcellular localization
- Mechanisms of internalization
Toxicology
- Cytokine release
- Bacterial endotoxin (LAL)
- Determining potential cytotoxicities in target tissues
- Elucidating toxicity mechanisms
- Drug screening to prevent cytotoxicity
- Cytochrome P450 induction studies
- Cr⁵¹ release
- Protein metabolism
- DNA synthesis
- RNA synthesis
- Dose range-finding investigation
- Hemolysis
- Plaque titering assays
- In vitro cytogenetics